Fallout 2 is great when you first get into it, so I say yes for that initial experience, however repeated playthroughs will have certain things get on your nerves to an extraordinary degree.
I can't step into New Reno anymore simply because the whole area reeks of sophomoric design to me, which is sad because the quests are so well done, I just tend to notice the retardation of it all too often (I hate the dialog for New Reno as well, Christ).
My last playthrough I didn't even really stop through there if I could help it, the same with San Francisco, I only went in when I needed to. I typically run over Modoc because that is my favorite of all Fallout locations (the atmosphere is perfect) and the quest with the Slags is one of my favorites of all the RPGs I've ever played in my life.
The game's sense of humor is less restrained than it is in the original and therefore it's got much less of a dark tone to it and more of a ridiculous vibe.
I much prefer the original Fallout, it's just choosing between one buggy piece of ass and another buggy piece of ass, fortunately, the first two Fallout games are buggy pieces of ass hollowed out and filled with gold.