I'd rather not. Not only is there yet another branch of the Brotherhood there hinted in F3, but the Enclave may still have a presence there too. I'd wait a game or 2. If anything, Fallout 5 will most likely take place in San Francisco. Bethesda outright told Obsidian they couldn't make a game there because Bethesda themselves wanted to, and like Fallout 3 referenced the commonwealth, they referenced San Francisco and the Shi in 4.
But this is exactly
why it'll happen.
They can drag out the corpses of the Enclave and 'Traditional' Brotherhood of Steel in an attempt to appeal to all fans. Here's the MwBoS, gone insular because they fucked up their empire. Here's the Enclave, rebuilding in Chicago, opening vaults, recruiting people, gassing wastelanders.
Add in some Mutant remnants (they already can grab Gammorin's Army). The way to do it right is to have it be a company of literal mini-bosses; not mooks. Mutants at this time would be organised, smart, and strong as hell, and once they die, they should stay dead.
It's perfect. The map will probably be a square from, Fallout Tactic's persepctive, the lake on the East, Gary in the South, Rockfalls and Freeport on the west. Who knows how far north they could go...Milwaukee maybe.
Think of the DLC. They can go East into Canada (Detroit as well). South to the plains. They can cook up something in Duluth.
Honestly it might happen. And I might play it. Fuck it. Dumb Fun inbound and maybe they have enough of a reaction to our whinging and whining that they write something passable than the bullshit in 4.