Great game, my first play through I used a male Brujah, they were good as a starter class, nothing special, the second time I used Tremere who are thus far my favorite clan, blood missle and blood shield become so useful, there was many a time I would've gotten beaten terribly if it wasn't for blood missles used in conjunction with the blood shield, plus, it's just always awesome to see your enemies explode into a big red cloud from blood boil.
I've started playing it again after quite a while and I'm playing as a Malkavian this time, it really is quite a bit more fun playing Malkavian though because of the funny dialogue and reactions you generally get by speaking with it, plus dementation is a pretty cool discipline as you get further along.
The one clan I've really not been able to pick up on though are the Nosferatu, I do like the clan itself, I like the whole hideous faced, stick to the shadows kinda style they have, but I just can't get around without breaking the friggin' masquerade so much from getting spotted, obfuscate does help alot, but I usually mess myself up from general anxiousness, they're a fun clan, but you need some patience and good timing.