You can, I set all my attributes to 1 when fiddling with the GECK and created an item that would do so.
I also refrained from putting points in weaponry skills, boosting up stuff like Barter and Speech, what I normally wouldn't use.
Keep in mind, this was all to squeeze some difficulty from the game, so far as I had played, Fallout 3 was one of the easiest gaming experiences I had ever had the "pleasure" of indulging myself.
The difficulty was on Very Hard, had some trouble early on, but once I reached level 5 everything became easy once again, decent Combat Armor, using the right drugs and the biggest knock against Fallout 3, being skillful during combat reduced the experience into one giant methodical crawl.
There was no difficulty in it at all, I just had to work combat correctly, dodge when right, use grenades at the appropriate moments, aim for the limbs. You might call this "tactics", but considering the pace of the game it was more like I was reacting right off the top of my head, instinctive action rather than premeditated action.
Too easy, all too easy, killed a Supermutant Master here or there with a Sledgehammer, bang in his arms and he can't do squat, get a good companion and everything is cheese.
The stats don't mean anything, the skills don't mean much beyond "You need 25 Lockpick to repair this door."
RPG? At this point I doubt it, RPG-lite? Not even, it ain't a RPG folks, pack up your bags, 1 Luck in SPECIAL means critical failures, nothing here, 1 Strength in SPECIAL means no weaponry, Fallout 3? Well I guess you can carry less. 1 Agility, oh, well I guess you can't use VATS as much!
Big deal, big deal, honestly, if the stats mean this little, then it means that no character is different, and if no character is different, what makes each "role" unique? Each character? I would say nothing, and if the possibility of a unique character doesn't exist, well then, where's that role that we put in the roleplaying?
Poof, it's gone.
Low stats need to cripple you, the question isn't the perspective, but rather, the fact that real time and Bethesda's overly cautious approach spawned a creature so fickle that it does not wish to suffer upon us a challenging experience.
Presumption! Insulting my and your intelligence.
How can you play it and not feel like a child, not feel like they're looking down upon you? You, who have defeated Fallout 1 on the hardest combat and game difficulty, yet now this simplicity? A shame.