Toilet Healing.
Um... That got old in Duke Nuke'em and has no place in a reality based game like fall out. (not to mention after 200 years the water in a toilet would've long since evaporated, unless it was in a ultra humid envrioment for condensation or open to rain fall. And even then, doubtful it'd heal you, and not be a breeding plot for mosquito larve or some nasty pond sum.
Dialogue.
Fallout 1&2 did it perfect with key npc's having spoken and the rest text. All spoken means less of it, which is never a good thing. And hearing the exact same half dozen or so voice actros repeatedly thoughout an entire game is a BIG peeve of mine. (I hated that about septerra core)
Fat Man.
Nukes brought about the appocalypse, fall of man, etc.. Now they're play toys? Ruins the realism, and is kinda pointless.
Rock-it.
Bleh, just let me sell the scrap metal to a dealer in town instead. (reminds me waaay to much of the junk gun from the rpg dead lands wasted west)
G.O.A.T. character creation.
Might be fun the first time, but an option to skip it is a must. (or if not hopefully added into it by a mod soon after like fans did to oblivion)
Mr. Liam Neeson's role.
*shrugs* Another overpaid movie star given a bigger wad of cash then they deserve just to read some pre written text. The money would've been far better spent on professional voice acting, especially the actor who did the intro VO's in the first 2 fallouts.
Weapons being degraded over time.
Once again, unrealastic and anoying. (S.t.a.l.k.e.r had it and it was infuraitingly pointless the idea a gun would wear out after only 50-100 rounds being fired through it. If modern rifles did that no solider woudl live through their first tour of duty.) Once again hopefully there's an option to turn it off, or a mod will be made to remove it entirely. (like was done with s.t.a.l.k.e.r) Now if they change it to needing to use a cleaning kit on the gun after every few hundred rounds, that makes sense, but still a needless addition/distraction from the main focus of the game.
How the environment has been translated.
Meh, eye candy is good an all, but not if it distracts from development of the storyline, world size, # of sub quests, etc..) And the exploding cars reminds me of something out of a loony toons cartoon. I'd almost expect critical failures on traps/ explosives/ grenade throwing leaving you painted black and blinking too.
I'm really having my doubts about Bethsada being able to do this with any quality, and wonder if maybe Bioware would've done better.
As my life partner told me (and she loved the original fallout games)
If they don't seriously change things and keep the same theme and quality of the originals it's going be Crapout 3 instead of Fallout 3.