For non-sociological experiments you don't need to use the Vaults though. Just use POWs in secret facilities, like Mariposa. The Vault 111 experiment was supposed to last only for 6 months. Maybe the governemnt built small towns around the Vaults just for the vault dwellers. Can you imagine the chaos if the 1000 Vault Dwellers had to reach the Vaults amidst the frightened doomed citizens? Not to mention that by being in the middle of nowhere there would be less risk of nukes targeting the area. Didn't Vault 8 receive the all-clear signal from the Enclave or I'm remebering it wrong?