I took a look at each of the Fallout openings (except Fallout 4. That game doesn't exist) to compare them. Fallout 3's opening is fucked (imo). Where Fallout, Fallout 2 and Fallout New Vegas give you some context about the world, the nuclear war, the Vaults, and the history of the area you're about to explore, Fallout 3 says this:
"War. War never changes.
Since the dawn of human kind, when our ancestors first discovered the killing power of rock and bone, blood has been spilled in the name of everything: from God to justice to simple, psychotic rage.
In the year 2077, after millennia of armed conflict, the destructive nature of man could sustain itself no longer. The world was plunged into an abyss of nuclear fire and radiation.
But it was not, as some had predicted, the end of the world. Instead, the apocalypse was simply the prologue to another bloody chapter of human history. For man had succeeded in destroying the world - but war, war never changes." The monologue then proceeds to lie to you about how no one has ever left Vault 101.
This opening monologue is stupid. It doesn't talk about war, it talks about humanity's capacity for violence. Since when has a war been fought over "simple, psychotic rage"? It attributes the 2077 nuclear war, not to battles over resources, but due to an inherent destructive part of human nature.
I'm sure there are people who agree with this. Conservative philosophy is based on the chief idea that humanity, without any kind of moral or lawful structure, descends into a state of nature little better than an animal, "nasty, brutish and short" (sorry if this isn't totally true. Studied politics aeons ago so my politics knowledge of Hobbes and Burke is a little rusty. Please don't turn this thread into a giant "conservative philosophy is actually blah blah...")
While I disagree with this conservative idea, I take no issue with it as the basis of a game. But I do take issue with it as a basis for a Fallout game. The other Fallout games leave it morally ambiguous about what causes humans to do what they do. Fallout, Fallout 2 and Fallout New Vegas don't place any kind of moral judgement on humanity from the get-go. They explain the reasons for the 2077 war: resources. And that's it. Make up your own mind as to why humanity shot itself in the foot.
While Interplay and Black Isle are saying, "War never changes" meaning that war never changes in its destruction of lives and livelihoods, Bethesda is saying, "War never changes" in the sense that humanity hasn't changed at all since we first figured out how to bash other humans over the head with rocks.
EDIT: tl;dr basically whereas Ron Perlman's narration in the original games was used to just give some facts about the player's situation, Fallout 3 uses the narration to express an opinion of human nature, and then narrative-wise mislead the player about the facts of Vault 101 for a later plot-twist.
(EVEN MORE EDIT: It's worth mentioning Ulysses in Fallout New Vegas as well. Ulysses' little monologue at the end of Lonesome Road also expresses an opinion of human nature when he says "war never changes but men do, with the roads they walk" (or something along those lines) the difference between this and Ron Perlman's Fallout 3 monologue is that Ulysses is a character with actual opinions. The ending of Lonesome Road is HIS opinion, not necessarily the game's or player's. By contrast, Rob Perlman is a disembodied voice whose word we are supposed to take as fact. By expressing an opinion of human nature, and deliberately misleading the player, it just makes me wonder who the Ron Perlman "character" is, when the original point was that he was just meant to be a characterless narrator giving you some historic context.)