1) DIALOGUE/VOICE ACTING NEEDS MAJOR IMPROVEMENT.
2) Better story, although from what I've heard it seems interesting. I just hope it's less Fallout-y like the previous ones that were all like this: Go here, find this, bring back, save day.
3) More consequences for actions, and less black and white morality, more gray areas like blowing up a town full of slavers, but at the same time you kill your best friend and slaves.
3) RETARDED CHARACTER!
This was probably one of my favorite features from the old games, I miss the ability to say "Nargh, me go now." "You sure room soundproof.... Me no want people to hear screams when me kill you!"(Or something like that.)
5) LARGER MAP!
Now for all the things I want:
I want reputation back. I dislike how when you help one town yet have negative karma in F3 this town hates you, and so do all the other towns.
Sex, sex, sex, we're old enough, you had sex in the last 3 just give us something to let us know we had sex, I mean at least a Mass Effect like scene, anything.
Weather, although on the Vault it says the Great War caused a permanent desert climate I'd still like to see weather.
BETTER ANIMATION, the animation was horrible, and the atmosphere was beautiful in the last game.
Less Mutants/Enclave/BoS please, I'd prefer to have more local problems, and heroes, if not, introduce a NEW enemy/hero, stop beating the dead horse.
Cults, I liked these from the originals, I think they should come back.
The BoS needs to be more like the old games, more of a gray organization than a white.
Less weapon degradation, this was a huge problem in F3 especially with armor like the T-51B Power Armor which couldn't be repaired yet took damage like a bitch, unless you had winterized of course.
Better humor, great humor in the old games, some funny moments in F3 just not HA-HA funny.
POWER ARMOR NEEDS TO BE THE END ALL BEST ARMOR IN THE GAME AND SHOULDN'T BE LYING ON EVERY FUCKING STREET CORNER.
Better science, less plot-holes, and less stupid design.
That about sums it all up, there's more but I feel like I covered most of it.
Of course, on its own it's a minor issue, my point was just to show that sex had some importance in FO2. But a overhaul of all mature themes in FONV would be nice : alcohol, sex and drugs need to be more than just buffs, magic potions and a lame way to waste caps... (which reminds me that caps ought to be gone from the game ! 
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