Not only that, but Fire Geckos don't even give you any loot for your trouble (unless you're playing with Killap's RP installed, in which case their mangy pelts, IIRC, are worth far less than a Golden's for roughly ten times the trouble).
Still, I've got to go with the Enclave Hit Squads. It's not often the original Fallouts made me feel cheated, but pitting you against a squad of commandos who can crit-kill you in one shot and letting them all get at least one shot off before you can escape to the worldmap is, at best, poorly thought-out, unless the devs' intent was to whittle down the size of the player's party (or more often, force repeated save/loads). What's worse is that the encounters are littered across plot-critical territory, and you (read: I) often get sucked into them even despite a downright wasteful amount of skill points pumped into Outdoorsman. To top it all off, by the time you usually find yourself running into them, you can't even really profit much from their loot.
While I'm on a tear, why the hell do I even have to get out of the car for these guys? Did they lure me out with a roadside lemonade stand? Maybe the old "My vertibird has a flat tire mister, could you help me out?" Even on a 3-INT playthrough, the first thing I think when I see a squad of power-armored evil goons packing state-of-the-art weaponry probably isn't "perhaps I should bring my vehicle to a full stop and then walk at least ten meters away from it." I know the same can be said of every encounter once you get the Highwayman, but with the really blisteringly unfair ones, it always felt even cheaper to me.