The game changes so much it's practically unrecognizable as Fallout. The gameplay is dumbed down to practically being a Call of Duty shooter, the lore is pretty much completely raped and killed and replaced with, whatever it is Bethesda thinks they are making (The Institute is the stupidest thing ever), and there is absolutely zero roleplaying. None what so ever. Who's idea was it to give the character a voice? And the stupid references to contemporary culture that they just throw in because, I dunno, laughs I guess. Yeah, the nuking the fridge was hilarious in 2008. Actually, no it never was.
Whatever. Fallout 4 isn't Fallout. Therefore, you aren't truly a Fallout fan if you love this game, as far as I'm concerned.