PossibleCabbage
Vault 22 Survivor
Hmm... Becoming addicted to something is down to both biology and personality. I could get on board if your charisma just made you slower to get addicted to things, even if endurance would make more sense in an in-universe context. I doubt we're going to have the ability to overdose on things in-game.
It all comes down to how they handle chems.
Because you can just smile at the bottle of booze and convince it not to make you an alcoholic.
Well, Charisma can represent genetic factors too. It wouldn't be unreasonable to say a low Charisma might correspond to various mental or personality disorders and having a high charisma therefore indicates that you don't have those sorts of issues. So perhaps having a high Charisma in this case corresponds to "not having an addictive personality".
"Not getting addicted to stuff" isn't really a matter of how tough you are, it's a matter of brain chemistry and you can't just assign everything to endurance.