I have a lot of thoughts about this:
For one I really appreciate the new art style. The scenery looks gorgeous, although I have to say some of the texture quality for the dog and the MC seemed a bit off to me.
That giant floating blimp looks... a little out there, but if we're dealing with the institute then sure, I'll be down to ride in one of those bad boys.
The new robot looks funky
It's very reminiscent of F03. The raiders in the supermarket, the BOS armour, even the locale. Again, very interesting.
I really hope the Enclave and BOS don't play a big part in this game. The Institute sounds interesting. Let them drive the plot.
Looks like we're getting voice acting. I'll be honest, I'm pretty worried if this turns out to be the case. I loved all the dialogue options in the other game, with voice acting we might lose that variety. Worst case scenario is we'll get something similar the Angry/Nice Guy/Sarcasm wheel from DA2, which will suck colossal dick.
All in all I'm excited. Really excited. Even the worst FO game is a still a very damn good game. Even though I do have my concerns I think it's gonna turn out amazing.