Just some thoughts:
I'm somewhat happy / optimistic to be honest. Atleast graphic-wise it's looking great so far (the world in teaser and in these latest shots). It's about the atmosphere, and i'm feeling it from those shots.
I'm very happy that the choice / conscience is still intact (we'll see in what degree though), but for the karma system, i'm not sure. It's of course a good thing that there's actually somekind of a measure to see what kind of person you are in the game, but i can only hope they have tweaked it a bit. For example, EVEN if your character was before, the cream of the cream (+300 karma, champion of all, wet dream of the ladies and daughters alike), that by doing some evil deed you would be able to destroy all of that good reputation, just because YOU made that choice to do it. I can't really remember how much you would've lost reputation in fallout 2 by, blowing Gecko's powerplant up, or super stimpacking tandi down, but the consciences should be harder then, eh, -100 karma?
It's quite hard to say how the combat system will work in action. What i only saw now was just a close combat encounter with an angry looking orc, odd (out of place) looking targeting system and that SLIGTHLY weird looking glimmering war hammer. Of course there was also the sweet motion blurred combat (big fucking deal) and the always-so-silly head explosion, a direct attempt for gore to show that THIS IS NOT A GAME FOR KIDDIES! What remains to be seen, is how combat from a distance, or how fighting 'n' targeting multiple enemies works. The idea of managing that from a first persion view feels, restricting to say the least, but i'm willing to give it a try. If done right, it might just be great.
However my personal biggest concern so far and what i'm fearing the most (for some reason) is that most the people / survivors in the wasteland will just be turned into this kind of faceless mass of enemies. No matter is it a mutant, ghoul or just evil-looking guy in a leather jacket with a scar around the cheek, they all just want to kill you. Any kind of real interaction / dialogue will be done between the merchants and your Dad. Next-gen survival horror action rpg adventure indeed.
I also dispise the whole dad aspect of the game. I just hope the whole "main quest" doesn't revolve around finding my... dad. Trapping radio signals, asking people around that "have you seen my dad!?" and after 30 hours of frustration you're ready to make that Choice to beat that ol' (runaway) bag into a bloody pulp, so i can continue my happy go go looting sessions. Of course this will be prevented because he's a vital part of the main quest, so for that reason alone he cannot be killed.
Speaking of those radio signals, i like the idea aswell, but to me it sounds so much like Oblivion's over-the-shoulder kind of quest fetching, but perhaps in a bit more frequent basis. Hmm.
Not sure how the lack of proper NPC's / companions will affect the game. Of course in the old fallouts it was WAY too easy to convince somebody to go with you, 'til the end or the world, if it's a must, but they totally gave a nice little spice to the game. Atleast i couldn't anymore play without Cassidy (gauss rifle) or Sulik (mega power fist). But, i don't see it as such a big problem though.
Ok, so now we finally have some more information of the game, but it's definitely still a very early glipse . It might suck totally, might be mediocore (propably) or super duper great, bestest in the world! However i CANNOT UNDERSTAND how some people can already say, that they're not going to buy the game, or those who say they're definitely going to buy the game, when we still have well over a year before the supposed release date.
It propably won't give the same fix as the first fallouts gave, and still do (i just don't think that there will ever be such masterpieces as they were), but even after all this ranting, i'm still anticipating a nice post-apocalyptic themed (RPG, hopefully) game.
It just doesn't feel like Fallout 3, even if i like most of the stuff which is there