I liked the piecemail armour approach, wearing things like the vault suit under leather.
The Glowing sea was pretty awesome the first time I started walking toward that weird shining light on the horizon and it brought me right back to the Glow in FO1.
I may get slaughtered for this haha, I actually ENJOYED the voiced protagonists *ducks behind cover* once I got got over the initial shock of how different it felt. Nora>>>Nate however.
And although it had so many problems, the settlement aspect. Just completely ignore the radiant quests after you get to the Talk to Preston stage, and the happiness stat, because it really has zero impact on anything.
Keep an outpost small and focused (6-10 settlers) and you can design some interesting way points for yourself.