From Tim Cain's GDC talk on Fallout:The original Fallout games are full of references that many fans took seriously but were meant to be fun. The Mad Max Uniform, Dogmeat, Robbie the Robot, and other movie references. I think its meant to be a silly reference-filled world.
"I was worried that not only we would lose players when had that but RPGs tend to sit on the shelf for years and I was afraid we'd look dated. So I made a rule and the rule for that was, if you put in a joke or cultural reference if the player didn't get it they shouldn't even know that that joke or cultural reference was being made."
And the slide bit says "Rule for jokes and references: If the player doesn't get them, they shouldn't even notice them."
There's a big difference in how Fallout 1 handled that compared to 2. I played this games in the last decade and while I got a lot of references in both I never felt like I was missing the joke in Fallout 1. I did a few times in Fallout 2 or that it was a joke I could tell and I could see some semblance of humor but I wasn't finding it funny. I don't hate Fallout 2 for it but I think Tim was very wise in his decision about making the joke in a way that if you can't get the humor or reference then you shouldn't even be able to tell you missed something. It really helps the situations not feel left behind in a cultural. I have a feeling games like Borderlands 3 will suffer this too. I've heard it is packed with a lot of the current internet humor that was popular during its development and was already kinda in the "old joke" category by the time it released.