Since Bethesda builds their games basically on a combat engine, does anybody think that potentially they ought to be exploring what Bioware was trying to do with the different play modes in Mass Effect 3? If you're unfamiliar, Bioware had three game options for playing ME3: Action, Story, and Roleplaying. The former skips all the character building and turns the interactive conversations into cutscenes, "story" de-emphasizes combat and character building but has full conversation trees, and "roleplaying" has everything.
I think this approach could easily be applied to a Beth game where you can simply choose how much of everything you want in your game. If you want character building with traits, skills, stats, and perks you can check that box. If you just want to shoot super mutants and don't want to worry about inventory limits you can check that box. If you want simplified conversations you can check that box.