A kind of a copy from my post to gamefaqs. Go ahead use it if you want.
Plot suggestion.
(after the intros and the ´war,war never changes´ thing,)
Start a new game: a movie.
You are in a vault resupply depot, you ether broke in or you were one of the rich ones you are leaded in the cryogenic wing (like in F2, Sierra Army Depot, Level 4 Bio Research Bay), but because of an accident, you can't use `your´ own cryogenic sustaining tube, it's broken so you have to use someone else's tube.
Now the game begins:
you won't get to make your char, you won't have even an inventory, there is 5 choices (you can read the tube sending addresses and you can swish them, changing some of the new worlds heroes, just like you)
-you can go to a empty,but damaged tube(and you will become a ghoul),
-or take one of the occupied tubes and kill the (wo)man inside,(the future's celebrities, which are adaptations of today's ones.
(ps: Michael Jackson))
(a movie based on your choice of tube)
you go to a sleep, the tubes are closed and frozen,
the tubes are transferred to 5 different vault's,
in 4 of the 5 vaults something horrible happens,
you are mutated, infected, and/or dissected and remade into 4 different races by the ultimate evil(you can see how the change happens, the one vault is attacked by mutated animals (the where you stay as a human), the tubes are opened something like 140-240 years after the great war.
(all in about the same time)
(the movies end)
So now you get to make your char, or take one of the pre-made ones(of each race have few) and after you ether escape or leave the place you have been bring into (5 different ones), you are given a mission to save the world for your race (only), all the races(humans, ghouls, super mutants, deathclaws(inserted whit your human brains), and a more modifiable humanoid robots (whit a human consciousness inserted into cyborg brain) have more than one base/city, so they each have their own and shared communities, and lots of quest's, although you can't solve them all in one play trough, some are, on the opposite sides, the ultimate evil side has many small bases including the ones the experiments are made in. (all the sides are nearly equal in playability, the ghouls can use power armor, the robots can bye perks from AI store; basically a computer, super mutants have more than a few armor types, deathclaws have their own way of doing things, stealth and blowing up some nukes etc.)
Middle: you can battle with and make peace treaties between the cities and the races, you get to meat the other `chosen´ones (they aren't called that, (ps: a ghoul or a super mutant Michael Jackson)), you can kill, join or ignore them according to the side you want to choice and you can even betray your own races side, like in F1, whit becoming a super mutant, but it don't change the race you are (and the game continues), you can even kill every one, and be happy for it. (and be the destroyer of world)
End: you solve some of your races missions, and some of the others, the last mission is to kill the ultimate evil, an enclave bishop, BOS general(from FT BOS, or the old ones in F1) or an alien mother in desgise, or some thing like that, that made it all starting things happen. Thought, if you don't want to kill the ultimate evil, you can join whit him/her and kill all the other faction leaders. (Ghouls, humans, super mutants, raiders, reavers, robots, NCR president, etc., taught some of them can to be killed already in sub missions), in the end you can even betray the ultimate evil. After the end cinematics, you can continue to play the game.
In the destroyer of the world end, once every one is dead, an enhanced random encounter happens,it's an ant, and if you
don't kill it at the first round it has only 1hp, it hits and kills you, and a end narration begins which says some thing like `just like dinosaur's reign of the world, the human's, ends in defeat and the new master races are insects. Let us belive it will be a better.´
If you kill it, it will re-happens again, again, again,etc. in the next random encounters.
The End.