Obsidian has the respect of the Mormons, a notoriously judgemental religion that dislikes any incorrect notions. I know some myself, and it pleases me to see them praise a game where obviously a lot of love and care has gone into it. Not to forget how Obsidian handles gays and other minorities. They're not ignored but they're not cartoon characters.
Oh definitely! Like Arcade for example. The first time I played through the game I didn't even know he was gay. You have to kinda scrounge to even find out unless you have the Confirmed Bachelor perk, and that's what I love. He isn't a stereotype, he doesn't come off as some flamboyant diva or anything, he's just a sarcastic doctor that wants to help people and just so happens to like dick.
I don't really recall other minorities in the game, unless you're referring to how ghouls have become synonymous with racial profiling. I think Obsidian handled it far better with their Jason Bright quest. First of all they're a ghoul faction seperated from everyone else, so you have to learn of why they want to leave through dialogue rather than seeing it, and actually have to talk in depth with them to figure out their motives. And there's the fact that Jason considers even Ferals a part of his flock and gets all sad when you kill them. Did you know that any ferals you don't kill in the main building will end up by the rocket ships with the nonferals when they launch? Actually I just realized Obsidian killed 2 birds with one stone with these guys. Not only do they represent a minority but they represent a religious minority as well to an extent. Well played Obsidian.
Meanwhile in Fallout 3 and 4 they literally beat you over the head with "GHOULS ARE A STAND-IN FOR MINORITIES IN AMERICA". I mean, for fuck's sake, every time Three Dog goes "And remember, Ghouls are people too" and immediately after says "Except the feral ones, shoot those on sight" I have to roll my eyes because it destroys the whole message first of all, and second of all, the only quest where you really help ghouls that are kinda being oppressed in Tenpenny Towers, the ghouls end up killing everyone anyway no matter what you do, which, in my opinion, would make anyone distrust ghouls quite a lot if they didn't before. It's just a convoluted mess, ESPECIALLY when fucking Three Dog chastises you for killing the ghouls even though we, the player, know the ghouls were planning to kill everyone in that tower. And when you DO let the Ghouls kill everyone in the tower, Three Dog's just like "Oh well, they were stuck up rich people anyway. Glad they're dead." Goddamn hypocrite. I'm sorry but that quest pisses me off, a lot.