Not really. Kinda half joking. I can't imagine them pulling of a realistic female lead though. I hardly like their male leads. Maybe some kind of Bonnie and Clyde thing would work. Aren't most mafioso types males? It just sounds...too far fetched. I can see it now - some hot blonde chick running around with daisy dukes and every guy in the game hitting on her. Maybe a Yakuza chick or a Latino badass would be plausible. Honestly, I'm tired of seeing female leads shoehorned into games that don't need it.
It seems like males are more prone to going apeshit and killing cops and driving 120 mph through traffic. How many woman go on mass murdering sprees? Sure there are plenty of woman criminals, but I usually see meth heads do stuff like that. Maybe make the female lead a huge meth addict. That would be believable. They would have to really make her believable or it would look stupid as shit. I'm so sick of seeing woman portrayed as ultra sexy Tomb Raider-esque killing machines. Not saying it couldn't be done, but doing it and doing it right are two different things.
Is it unreasonable to want something that makes sense? How many woman are in the mob for instance? Other than in the movies of course. Sure GTA isn't supposed to be realistic, but I like it to be kinda believable. Maybe the female lead was raped and left for dead by some shady types and she is out for revenge. That might work, even though it's been done to death. I'm just struggling to imagine what it would look like in GTA.
Hell, I wouldn't mind if they did it good, but I often find their portrayals in video games to be outright absurd. The female characters in GTA 4 sucked for the most part. I do remember Rockstar talking about this same subject before and they didn't seem to think it was a good idea either. At any rate, I don't feel strongly opposed to it, as I said before, so take that for what it's worth.