If I were to revive the Enclave in the most stereotypical manner, I admit, I'd probably do it like this:
Fallout 5: Lake City
The player character is THE SCOUT from across the Great Wasteland separating the Mojave from the Midwest. Having successfully traversed the region, they have the mission to acquire a full report and deliver it back to the Bishop Caravan Company.
The region of Lake City is torn up as the Midwestern Brotherhood of Steel has been decimated by a guerilla warfare from THE NEW AMERICANS which consists of locals who are engaged in a campaign of terrorist resistance against their feudal overlords. They engage in murder, killing collaborators, and generally fighting the MBoS asymetrically because they can't win in a stand-up fight.
The PCs will have the option of visiting all the local regions as they see what it's like with the feudal MBoS and it's good as well as bad points. If they ally with the New Americans, though, they can eventually find the keys to Vault 100 and discover the New Americans are being sponsored by duh-duh-duh THE ENCLAVE.
After the destruction of Navarro and the Enclave evacuated to Raven's Rock, a group of them settled down in Chicago and discovered a still-intact Vault of humans with a Super-Patriotic theme. Trusting this group of fellow "pure" humans more than they did a nebulous voice claiming to be the President, they took over and promptly constructed their own underground society which had used the GECK inside to make fertile.
The NEO-ENCLAVE as they self-identify is currently divided into three groups with the group which has softened its speciest stance and wants to conquer the surrounding Lake City and replace the MWBoS with their own government. The irony is they're actually believers in Democracy, freedom, and other ideals. They intend to incorporate the mutated wastelanders into their new home. Opposing them is the Isolationist faction which is a bunch of nasty racists but also believe conquering people is wrong.
The PCs can support one faction or the other and wreck the side which they don't want to be predominate. They can also blow it up for the MWBoS.
And to TOTALLY SCREW WITH WHAT WE EXPECT FROM FALLOUT, if you have maximized rep with both and make the right decisions, you can arrange a peace treaty so NOBODY very few people die.